A glycosylated complex of gadolinium, a new potential contrast agent for magnetic resonance angiography?

Authors :: Yu G
Yamashita M
Aoshima K
Takahashi M
Oshikawa T
Takayanagi H
Laurent S
Burtea C
Vander Elst L
Muller RN
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Apr 15; Vol. 17 (8), pp. 2246-9. Date of Electronic Publication: 2007 Jan 27.
Publication Year :: 2007
Abstract: A new low-molecular weight dendrimer-like MRI contrast agent (Gd-D1) has been synthesized and characterized in vitro by proton and oxygen-17 relaxometry. Its pharmacokinetic parameters and biodistribution patterns were evaluated on rats. Its in vitro and in vivo properties, that is, the longitudinal relaxivity (defined as the increase of the water proton longitudinal relaxation rate induced by one millimole per liter of Gd-D1) equal to 5.6s(-1)mM(-1) at 20 MHz and 310 K, the elimination half-time equal to 85 min, and its low accumulation in liver and spleen, underline its potential as a blood-pool MRI contrast agent.<br /> ((c)2000 Elsevier Science Ltd. All rights reserved.)

Subjects :: Animals
Contrast Media pharmacokinetics
Dendrimers
Gadolinium pharmacokinetics
Glycosylation
Liver metabolism
Molecular Weight
Oxygen Isotopes
Pharmacokinetics
Protons
Rats
Spleen metabolism
Tissue Distribution
Contrast Media chemistry
Gadolinium chemistry
Magnetic Resonance Angiography methods

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