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[Testicular malignant tumours. Efficacy of germ cell and sex cord tumours treatment protocol in Poland].
- Source :
-
Medycyna wieku rozwojowego [Med Wieku Rozwoj] 2006 Jul-Sep; Vol. 10 (3 Pt 1), pp. 811-7. - Publication Year :
- 2006
-
Abstract
- Unlabelled: Approximately 2% of of all malignant tumours in boys are localised in the testis. Among them 80% are germ cell tumours with the malignant elements of yolk sac tumour. AIM of the study was evaluation of the efficacy of malignant testicular tumour treatment programme in children.<br />Material and Methods: Since 1998 31 boys aged 1 month to 18 years (median 14 years) with malignant testicular tumours were enrolled in the multicentre trial. Patomorphologically clear yolk sac tumour (33%) and mixed germ cell tumour (42%) with the majority of yolk sac tumour component or carcinoma embryonale, occurred most often. Alfa-feto-protein was increased in 63% and choriogonadotropin in 26 patients. 61% patients had local clinical stage and the tumour was localized in the testis. In 39% patients tumour exceeded the testis margin. 4 patients were excluded from analysis as 3 are actually treated and 1 died on the second day of admittance to hospital. All patients received TGM 95 regimen (Tumeurs Germinales Malignes). Surgery (orchidectomy) was applied in 27 boys, 26 were primary (81% complete), 3 secondary (100% complete). 33% received no chemotherapy after surgery, in 41% VBP protocol (vinblastine, bleomycin, cisplatin) was given and in 26%o VIP protocol (ethoposide, ifosphamide, cisplatin). Two patients received also ABK (adriamycine, bleomycin, carboplatin).<br />Results: Among 26 children with germ cell tumours, 25 (96%) are alive, 23 (88%) are in first remission after completion of treatment. One child died due to central nervous system metastases. 2 children had local recurrence treated with chemotherapy or surgery with good result. Median follow-up is 45 months.<br />Conclusions: TGM regimen is highly efficient in the treatment of malignant testicular tumours. Problems occur in cases of disseminated disease.
- Subjects :
- Adolescent
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Bleomycin administration & dosage
Carboplatin administration & dosage
Child
Child, Preschool
Cisplatin administration & dosage
Doxorubicin administration & dosage
Drug Administration Schedule
Endodermal Sinus Tumor drug therapy
Etoposide administration & dosage
Humans
Ifosfamide administration & dosage
Male
Neoplasms, Germ Cell and Embryonal pathology
Poland
Remission Induction
Sex Cord-Gonadal Stromal Tumors pathology
Testicular Neoplasms pathology
Treatment Outcome
Vincristine administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Neoplasms, Germ Cell and Embryonal drug therapy
Sex Cord-Gonadal Stromal Tumors drug therapy
Testicular Neoplasms drug therapy
Subjects
Details
- Language :
- Polish
- Volume :
- 10
- Issue :
- 3 Pt 1
- Database :
- MEDLINE
- Journal :
- Medycyna wieku rozwojowego
- Publication Type :
- Academic Journal
- Accession number :
- 17317912