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Emerging roles of nuclear protein phosphatases.
- Source :
-
Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2007 Mar; Vol. 8 (3), pp. 234-44. - Publication Year :
- 2007
-
Abstract
- The phosphorylation state of any protein represents a balance of the actions of specific protein kinases and protein phosphatases. Many protein phosphatases are highly enriched in, or exclusive to, the nuclear compartment, where they dephosphorylate key substrates to regulate various nuclear processes. In this review we will discuss recent findings that define the role of nuclear protein phosphatases in controlling transforming growth factor-beta (TGFbeta) and bone-morphogenetic protein (BMP) signalling, the DNA-damage response, RNA processing, cell-cycle progression and gene transcription.
- Subjects :
- Animals
Bone Morphogenetic Proteins metabolism
Cell Cycle
Cell Nucleus metabolism
DNA Damage
Humans
Protein Kinases metabolism
RNA Processing, Post-Transcriptional
Signal Transduction
Transcription, Genetic
Transforming Growth Factor beta metabolism
Cell Nucleus enzymology
Phosphoprotein Phosphatases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1471-0072
- Volume :
- 8
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nature reviews. Molecular cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 17318227
- Full Text :
- https://doi.org/10.1038/nrm2126