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Control of virus infection by tumour suppressors.
- Source :
-
Carcinogenesis [Carcinogenesis] 2007 Jun; Vol. 28 (6), pp. 1140-4. Date of Electronic Publication: 2007 Mar 07. - Publication Year :
- 2007
-
Abstract
- An increasing number of tumour suppressor genes are induced by interferons (IFNs) and may play an important role in the control of cell proliferation induced by this cytokine. In addition, pathways triggered by both tumour suppressors and IFN converge as common targets for non-related tumour viruses. The inhibition of the IFN response by animal viruses is explained by the fundamental role that IFN plays to control virus infection. However, the reasons why many viruses, including those that do not require the replication of the host, target tumour suppressor pathways are varied and are still under investigation. Here we review those findings that support that tumour suppressors may have a role in the control of virus infection.
- Subjects :
- Animals
Humans
Interferons antagonists & inhibitors
Interferons physiology
Tumor Suppressor Proteins biosynthesis
Tumor Suppressor Proteins genetics
Virus Diseases enzymology
Virus Diseases genetics
Gene Expression Regulation, Viral physiology
Genes, Tumor Suppressor
Tumor Suppressor Proteins physiology
Virus Diseases metabolism
Virus Diseases prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0143-3334
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 17347139
- Full Text :
- https://doi.org/10.1093/carcin/bgm048