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Phosphonoxins: rational design and discovery of a potent nucleotide anti-Giardia agent.

Authors :
Suk DH
Rejman D
Dykstra CC
Pohl R
Pankiewicz KW
Patterson SE
Source :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 May 15; Vol. 17 (10), pp. 2811-6. Date of Electronic Publication: 2007 Feb 25.
Publication Year :
2007

Abstract

Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.

Details

Language :
English
ISSN :
0960-894X
Volume :
17
Issue :
10
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
17360182
Full Text :
https://doi.org/10.1016/j.bmcl.2007.02.063