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Early social isolation decreases the expression of calbindin D-28k and dendritic branching in the medial prefrontal cortex of the rat.
Early social isolation decreases the expression of calbindin D-28k and dendritic branching in the medial prefrontal cortex of the rat.
- Source :
-
The International journal of neuroscience [Int J Neurosci] 2007 Apr; Vol. 117 (4), pp. 465-76. - Publication Year :
- 2007
-
Abstract
- Social isolation in rodents is the most well characterized animal model for early stressful experiences and their neurobehavioral consequences. The present study analyzed the effects of early social isolation on the expression of the calcium binding protein calbindin-D28k (CAD) and dendritic arborization in the medial prefrontal cortex (mPFC) of the rat. Sprague-Dawley male rats were reared either under isolation or social conditions from 21 to 51 postnatal days. At the end of this period the animals were behaviorally evaluated in the open-field test, sacrificed, and mPFC serial sections were processed either for immunocytochemical labeling against CAD or Golgi-Cox-Sholl staining. Isolated-reared rats exhibited a dramatic decrease in the number of CAD immunoreactive neurons and a significant dendritic atrophy of layer II/III pyramidal cells in association with a reduced exploratory behavior.
- Subjects :
- Animals
Animals, Newborn
Behavior, Animal
Calbindin 1
Calbindins
Exploratory Behavior physiology
Immunohistochemistry methods
Male
Rats
Rats, Sprague-Dawley
Dendrites physiology
Gene Expression Regulation, Developmental physiology
Prefrontal Cortex metabolism
Prefrontal Cortex ultrastructure
S100 Calcium Binding Protein G metabolism
Social Isolation psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0020-7454
- Volume :
- 117
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The International journal of neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 17365129
- Full Text :
- https://doi.org/10.1080/00207450600773459