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Structural biology of RNA silencing and its functional implications.
- Source :
-
Cold Spring Harbor symposia on quantitative biology [Cold Spring Harb Symp Quant Biol] 2006; Vol. 71, pp. 81-93. - Publication Year :
- 2006
-
Abstract
- We outline structure-function contributions from our laboratories on protein-RNA recognition events that monitor siRNA length, 5 -phosphate and 2-nucleotide 3 overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release.
- Subjects :
- Bacterial Proteins chemistry
Bacterial Proteins genetics
Bacterial Proteins metabolism
Humans
MicroRNAs biosynthesis
Models, Biological
Models, Molecular
Peptide Initiation Factors chemistry
Peptide Initiation Factors genetics
Peptide Initiation Factors metabolism
Protein Structure, Tertiary
RNA, Messenger chemistry
RNA, Messenger genetics
RNA, Messenger metabolism
RNA, Small Interfering chemistry
RNA, Small Interfering genetics
RNA, Small Interfering metabolism
Ribonuclease III metabolism
Viral Proteins chemistry
Viral Proteins genetics
Viral Proteins metabolism
RNA Interference
Subjects
Details
- Language :
- English
- ISSN :
- 0091-7451
- Volume :
- 71
- Database :
- MEDLINE
- Journal :
- Cold Spring Harbor symposia on quantitative biology
- Publication Type :
- Academic Journal
- Accession number :
- 17381284
- Full Text :
- https://doi.org/10.1101/sqb.2006.71.053