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A phase III study in lung carcinoma comparing hexamethyl-melamine (NSC 13875) to dibromodulcitol (NSC 104800) 1,2.
- Source :
-
Oncology [Oncology] 1975; Vol. 31 (5-6), pp. 293-309. - Publication Year :
- 1975
-
Abstract
- A phase III study was designed comparing the effectiveness of Hexamethyl-melamine (NSC 13875) to Dibromodulcitol (NSC 104800) in lung carcinoma. 250 of the 316 patients entered on the study were stratified into groups according to stage of disease and cell type. The results showsed Hexamethylmelamine to be more effective in patients with squamous cell carcinoma and slightly superior to Dibromodulcitol in patients with anaplastic/undifferentiated cell carcinoma, whereas Dibromodulcitol proved to be more effective in patients with adenocarcinoma.
- Subjects :
- Altretamine adverse effects
Clinical Trials as Topic
Drug Evaluation
Humans
Leukopenia chemically induced
Middle Aged
Mitolactol adverse effects
Nausea chemically induced
Thrombocytopenia chemically induced
Vomiting chemically induced
Adenocarcinoma drug therapy
Altretamine therapeutic use
Carcinoma, Small Cell drug therapy
Carcinoma, Squamous Cell drug therapy
Lung Neoplasms drug therapy
Mitolactol therapeutic use
Triazines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0030-2414
- Volume :
- 31
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 174041
- Full Text :
- https://doi.org/10.1159/000225036