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Complement components, regulators and receptors are produced by human monocyte-derived dendritic cells.
- Source :
-
Immunobiology [Immunobiology] 2007; Vol. 212 (3), pp. 151-7. Date of Electronic Publication: 2007 Jan 03. - Publication Year :
- 2007
-
Abstract
- Complement and dendritic cells (DCs) are essential components of innate immunity. Both participate in local inflammation and moreover have roles in the initiation of the acquired immunity response and in the maintenance of tolerance. Recent studies have demonstrated the ability of DCs to synthesize C1q, C3, Factor I, Factor B and complement receptors 3 and 4. In this study, we demonstrate that human DCs are a source of other soluble complement proteins including C1q, C4b binding protein (C4BP), C7 and C8. Complement receptors (CR)1 and the CD18 chain (common for CR3 and CR4) were also present on DCs while CR2 was not detected.
- Subjects :
- Cell Differentiation immunology
Cell Lineage immunology
Cells, Cultured
Dendritic Cells cytology
Dendritic Cells immunology
Humans
Immunity, Innate
Immunophenotyping
Macrophages immunology
Macrophages metabolism
Monocytes immunology
Monocytes metabolism
Complement Inactivator Proteins biosynthesis
Complement System Proteins biosynthesis
Dendritic Cells metabolism
Monocytes cytology
Receptors, Complement biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0171-2985
- Volume :
- 212
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Immunobiology
- Publication Type :
- Academic Journal
- Accession number :
- 17412282
- Full Text :
- https://doi.org/10.1016/j.imbio.2006.11.010