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Toll-like receptor 4 Asp299Gly polymorphism is associated with an increased risk of pancreatic necrotic infection in acute pancreatitis: a study in the Chinese population.
- Source :
-
Pancreas [Pancreas] 2007 Apr; Vol. 34 (3), pp. 295-8. - Publication Year :
- 2007
-
Abstract
- Objectives: To detect the frequency of Toll-like receptor (TLR) 4896A>G (Asp299Gly) polymorphism in acute pancreatitis (AP) patients and to determine the relationship between polymorphism and pancreatic necrotic infection.<br />Methods: The allele frequency of TLR4 Asp299Gly was surveyed by mispairing polymerase chain reaction-restriction fragment length polymorphism analysis technique in AP patients with pancreatic necrosis and healthy volunteers, respectively.<br />Results: All individuals with TLR4 Asp299Gly polymorphism were heterozygotes. Compared with healthy volunteers (5.6%), TLR4 896G allele frequencies was significantly higher in AP patients with pancreatic infection (20%), the incidence of gram-negative infection was significantly higher in AP patients with TLR4 Asp299Gly polymorphism (15 [44%]/34) than that in AP patients without TLR4 polymorphism (15 [18%]/81).<br />Conclusions: Toll-like receptor 4 Asp299Gly polymorphism is associated with the infection of pancreatic necrosis in AP. Patients who carried TLR4 896A>G mutation is susceptible to pancreatic gram-negative bacteria infection.
- Subjects :
- APACHE
Adult
Aspartic Acid
Bacterial Infections complications
China
Female
Gene Frequency
Genetic Variation
Glycine
Humans
Male
Middle Aged
Necrosis
Pancreatitis etiology
Pancreatitis microbiology
Restriction Mapping
Risk Factors
Amino Acid Substitution
Pancreatitis genetics
Pancreatitis pathology
Polymorphism, Genetic
Toll-Like Receptor 4 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4828
- Volume :
- 34
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pancreas
- Publication Type :
- Academic Journal
- Accession number :
- 17414051
- Full Text :
- https://doi.org/10.1097/mpa.0b013e318032674a