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Antiplatelet activity of geranylgeraniol isolated from Pterodon pubescens fruit oil is mediated by inhibition of cyclooxygenase-1.
- Source :
-
Planta medica [Planta Med] 2007 May; Vol. 73 (5), pp. 480-3. Date of Electronic Publication: 2007 Apr 18. - Publication Year :
- 2007
-
Abstract
- Geranylgeraniol is a natural isoprenoid with anti-inflammatory properties extracted from the Pterodon pubescens Benth. fruit oil (PpO). In this work, the antiplatelet effect of both PpO and geranylgeraniol is investigated. ADP-, thrombin- and arachidonic acid (AA)-induced aggregation in human and rabbit platelets showed a prime involvement of PpO and geranylgeraniol in the arachidonic acid cascade. The lack of any significant inhibition of platelet aggregation induced by U-46 619 and thrombin, associated with PpO and geranylgeraniol suppression of prostaglandin E(2) and thromboxane A(2) formation demonstrate, for the first time, the involvement of geranylgeraniol in the AA metabolisation by inhibiting the cyclooxygenase enzyme.
- Subjects :
- Animals
Arachidonic Acid metabolism
Cyclooxygenase 1 metabolism
Cyclooxygenase Inhibitors chemistry
Cyclooxygenase Inhibitors isolation & purification
Diterpenes chemistry
Diterpenes isolation & purification
Humans
Plant Oils chemistry
Plant Oils isolation & purification
Platelet Aggregation Inhibitors chemistry
Platelet Aggregation Inhibitors isolation & purification
Rabbits
Cyclooxygenase Inhibitors pharmacology
Diterpenes pharmacology
Fabaceae chemistry
Fruit chemistry
Plant Oils pharmacology
Platelet Aggregation Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0032-0943
- Volume :
- 73
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 17443436
- Full Text :
- https://doi.org/10.1055/s-2007-967177