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Changes in leptin serum levels in HIV-infected children receiving highly active antiretroviral therapy.
- Source :
-
Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 2007; Vol. 67 (3), pp. 291-6. - Publication Year :
- 2007
-
Abstract
- Highly active antiretroviral therapy (HAART) has significantly improved the prognosis of HIV(+) in children. Human immunodeficiency-associated lipodystrophy syndrome (HALS) is a side effect of HAART seen predominantly in adults and less often in children. Leptin is a protein thought to play an important role in body composition and has been shown to have immunomodulatory effects. We retrospectively studied serum levels of leptin in a cohort of eight HIV-infected children followed prospectively before and during HAART and investigated whether there is a correlation of these levels with the clinical, immunological, viral or nutritional changes observed during treatment in these children. None of our children developed HALS. In this small cohort of children, we found that serum leptin levels were appropriate to the nutritional status of the patient and that leptin/BMI increased in patients who responded to HAART. In conclusion, in HIV(+) children during HAART, leptin levels are related to the nutritional status of the child.
- Subjects :
- Acquired Immunodeficiency Syndrome complications
Adult
Body Mass Index
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes immunology
Child
Child, Preschool
Cohort Studies
Female
HIV
HIV-Associated Lipodystrophy Syndrome physiopathology
HIV-Associated Lipodystrophy Syndrome virology
Humans
Infant
Male
Nutritional Status drug effects
Retrospective Studies
Statistics, Nonparametric
Viral Load
Acquired Immunodeficiency Syndrome blood
Acquired Immunodeficiency Syndrome drug therapy
Anti-HIV Agents therapeutic use
Antiretroviral Therapy, Highly Active
HIV-Associated Lipodystrophy Syndrome prevention & control
Leptin biosynthesis
Leptin blood
Subjects
Details
- Language :
- English
- ISSN :
- 0036-5513
- Volume :
- 67
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of clinical and laboratory investigation
- Publication Type :
- Academic Journal
- Accession number :
- 17454843
- Full Text :
- https://doi.org/10.1080/00365510601045062