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Relationship between insulin resistance and serum levels of adiponectin and resistin with childhood obesity.
- Source :
-
Indian pediatrics [Indian Pediatr] 2007 Apr; Vol. 44 (4), pp. 275-9. - Publication Year :
- 2007
-
Abstract
- Objective: The aim is to study the relationship between insulin resistance and serum adiponectin and resistin in obese children.<br />Methods: A total 113 obese and 37 nonobese children were enrolled and serum adiponectin and resistin were measured.<br />Results: Compared with controls, higher insulin resistance by homeostasis model (HOMA-IR) and lower whole body insulin resistance index (WBISI)were found in obese children (all P <0.05). The adiponectin levels in obese children and controls were 3.63 and 5.79 microg/L with a significant difference (P<0.001) while the difference of resistin levels was not significant (P = 0.948). Significant correlations between insulin resistance parameter and age,sexual development, BMI, serum triglyceride, ApoB, LDL-cholesterol, HDL-cholesterol, alanine aminotransferase, uric acid, or adiponectin levels (all P <0.05) were noted. Stepwise multiple regression analysis showed that BMI and adiponectin levels were independent determinants of WBISI.<br />Conclusions: These results suggest that adiponectin may play a protective role in obese children through decreasing insulin resistance.
Details
- Language :
- English
- ISSN :
- 0019-6061
- Volume :
- 44
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Indian pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 17468522