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Cutting edge: conventional dendritic cells are the critical APC required for the induction of experimental cerebral malaria.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2007 May 15; Vol. 178 (10), pp. 6033-7. - Publication Year :
- 2007
-
Abstract
- Cerebral malaria (CM) is a serious complication of Plasmodium falciparum infection, causing significant morbidity and mortality among young children and nonimmune adults in the developing world. Although previous work on experimental CM has identified T cells as key mediators of pathology, the APCs and subsets therein required to initiate immunopathology remain unknown. In this study, we show that conventional dendritic cells but not plasmacytoid dendritic cells are required for the induction of malaria parasite-specific CD4+ T cell responses and subsequent experimental CM. These data have important implications for the development of malaria vaccines and the therapeutic management of CM.
- Subjects :
- Animals
Antigen Presentation genetics
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes parasitology
Cell Death genetics
Cell Death immunology
Dendritic Cells parasitology
Female
Humans
Immunity, Cellular genetics
Malaria, Cerebral pathology
Malaria, Cerebral prevention & control
Mice
Mice, Inbred C57BL
Mice, Transgenic
Plasmodium falciparum immunology
Spleen immunology
Spleen parasitology
Spleen pathology
Antigen Presentation immunology
Dendritic Cells classification
Dendritic Cells immunology
Malaria, Cerebral immunology
Malaria, Cerebral parasitology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 178
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 17475826
- Full Text :
- https://doi.org/10.4049/jimmunol.178.10.6033