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Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives.

Authors :
Zhu B
Marinelli BA
Abbanat D
Foleno BD
Bush K
Macielag MJ
Source :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Jul 15; Vol. 17 (14), pp. 3900-4. Date of Electronic Publication: 2007 May 03.
Publication Year :
2007

Abstract

A series of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives has been synthesized. The best compounds in this series possess potent in vitro antibacterial activity against erythromycin-susceptible and erythromycin-resistant bacteria.

Subjects

Subjects :
Erythromycin analogs & derivatives
Microbial Sensitivity Tests
Staphylococcus aureus drug effects
Streptococcus pneumoniae drug effects
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents pharmacology
Erythromycin chemical synthesis
Erythromycin pharmacology

Details

Language :
English
ISSN :
0960-894X
Volume :
17
Issue :
14
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
17502142
Full Text :
https://doi.org/10.1016/j.bmcl.2007.04.104
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