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Human papillomavirus prevalence and predictors for cervical cancer among high-risk women from Rio de Janeiro, Brazil.
- Source :
-
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2007 May-Jun; Vol. 17 (3), pp. 651-60. - Publication Year :
- 2007
-
Abstract
- We assess the prevalence of human papillomavirus (HPV) and cofactors for cervical severe disease, as contribution for vaccine strategies at the right moment in which Brazilian health authorities have approved an anti-HPV vaccine. A case-control study was undertaken with 201 women who attended a public health service with previous abnormal cytology. The HPV status was ascertained by consensus primers My09/11 and typed by 6, 11, 16, 18, 31, 33, 35, and 58 specific primers. Patients diagnosed with high-grade squamous intraepithelial lesions (HSIL) and cervical cancer were referred as cases (n = 84). Patients with normal/inflammatory cervix or carrying benign cervical lesions were included in controls (n = 117). The overall prevalence of HPV infection was 75.6%, with 91.7% among cases. In spite of HPV 16 being the most frequent type (53.3%), 27.6% of infections were attributed to nonvaccine types. High-risk HPV were strongly associated to older women (OR = 6.7). Otherwise, age at the first intercourse (OR = 7.10), three or more parities (OR = 3.05), abortion episodes (OR = 4.80), and smoking (OR = 3.83) conferred a heavy effect in younger women. Among mediators affecting the progress from HSIL to cancer, age played the main role in easing the progression (OR = 1.09, P = 0.002) followed by education level (OR = 4.20, P = 0.066). White ethnia showed to be a protective factor (OR = 0.32, P = 0.055). Predictors from HPV exposure to malignant disease include demographic and behavioral factors. Public policies such as improvement of education and continued prevention campaigns might contribute to reduce this picture. This work also gives background, in identifying a target population, for implementing future vaccine strategies.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Brazil epidemiology
Case-Control Studies
Female
Humans
Life Style
Middle Aged
Papillomavirus Infections diagnosis
Prevalence
Prognosis
Risk Factors
Sexual Behavior
Social Class
Uterine Cervical Neoplasms etiology
Uterine Cervical Dysplasia etiology
Papillomavirus Infections epidemiology
Uterine Cervical Neoplasms diagnosis
Uterine Cervical Dysplasia diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1048-891X
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
- Publication Type :
- Academic Journal
- Accession number :
- 17504378
- Full Text :
- https://doi.org/10.1111/j.1525-1438.2007.00844.x