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[The effect of arginine on cytochrome P-450 activity and the structural state of the microsomal membranes of the rat liver and testes].
- Source :
-
Nauchnye doklady vysshei shkoly. Biologicheskie nauki [Nauchnye Doki Vyss Shkoly Biol Nauki] 1991 (9), pp. 28-34. - Publication Year :
- 1991
-
Abstract
- A single intraperitoneal arginine injection increases the amidopyrin demethylation on 230% and aniline hydroxylation on 74% in rat liver microsomes. For all this the rate of lipid peroxidation estimated by the number of dienic conjugates and Schiff bases does not change. At the same time the exogenous arginine decreases the lipid bilayer microviscosity on 35% and increases the degree of protein submersion into lipid matrix on 54%. The experiments in vitro confirm the fact of activation in cytochrome P-450 isoform by arginine. A possible arginine effect on microsome membrane is under discussion.
- Subjects :
- Animals
Cytochrome P-450 Enzyme System metabolism
Intracellular Membranes enzymology
Lipid Peroxidation drug effects
Male
Membrane Fluidity drug effects
Microsomes enzymology
Microsomes, Liver enzymology
Rats
Testis enzymology
Viscosity
Arginine pharmacology
Cytochrome P-450 Enzyme System drug effects
Intracellular Membranes drug effects
Microsomes drug effects
Microsomes, Liver drug effects
Testis drug effects
Subjects
Details
- Language :
- Russian
- ISSN :
- 0470-4606
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nauchnye doklady vysshei shkoly. Biologicheskie nauki
- Publication Type :
- Academic Journal
- Accession number :
- 1751615