Killer cell Ig-like receptors CD158a and CD158b display a coactivatory function, involving the c-Jun NH2-terminal protein kinase signaling pathway, when expressed on malignant CD4+ T cells from a patient with Sezary syndrome.

Subjects

Subjects :

CD3 Complex biosynthesis
Cell Proliferation
Humans
Immunoglobulins chemistry
Killer Cells, Natural metabolism
Leukocytes, Mononuclear cytology
Leukocytes, Mononuclear metabolism
Receptors, KIR
Receptors, KIR2DL1
Receptors, KIR2DL3
CD4-Positive T-Lymphocytes immunology
Gene Expression Regulation
JNK Mitogen-Activated Protein Kinases chemistry
Receptors, Immunologic biosynthesis
Sezary Syndrome blood
Sezary Syndrome immunology
Signal Transduction

Details

Language :

English

ISSN :

0006-4971

Volume :

109

Issue :

11

Database :

MEDLINE

Journal :

Blood

Publication Type :

Report

Accession number :

17522341

Full Text :

https://doi.org/10.1182/blood-2007-02-071993