Back to Search Start Over

How pattern recognition receptor triggering influences T cell responses: a new look into the system.

How pattern recognition receptor triggering influences T cell responses: a new look into the system.

Authors :
Padovan E
Landmann RM
De Libero G
Source :
Trends in immunology [Trends Immunol] 2007 Jul; Vol. 28 (7), pp. 308-14. Date of Electronic Publication: 2007 May 29.
Publication Year :
2007

Abstract

Signaling through pattern recognition receptors (PRRs) in antigen-presenting cells (APCs) is required for the induction of T cell responses. PRR triggering in APCs induces important cellular modifications that have profound effects on antigen internalization, processing, MHC loading and antigen presentation. Accumulating experimental evidence also suggests that the fate of T cell responses depends strongly on the type of PRR triggered and the timing of PRR signaling. Here, we discuss the beneficial effects of PRR stimulation in the context of priming naive T cells, the generation and maintenance of effector/memory T cells, and the induction or break of tolerance. We propose a new classification into opsonic, phagocytic and instructive PRRs based on the functional properties of the receptors.

Details

Language :
English
ISSN :
1471-4906
Volume :
28
Issue :
7
Database :
MEDLINE
Journal :
Trends in immunology
Publication Type :
Academic Journal
Accession number :
17537673
Full Text :
https://doi.org/10.1016/j.it.2007.05.002