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Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjects.

Authors :
Juengst SB
Aizenstein HJ
Figurski J
Lopez OL
Becker JT
Source :
Journal of neuroscience methods [J Neurosci Methods] 2007 Jul 30; Vol. 163 (2), pp. 208-12. Date of Electronic Publication: 2007 Mar 13.
Publication Year :
2007

Abstract

Functional magnetic resonance imaging (fMRI) has revealed much about altered CNS function in HIV/AIDS. In this study, we compared the blood oxygen level dependent hemodynamic response function (BOLD HRF) signal in HIV/AIDS and control subjects as a necessary pre-condition for fMRI studies of higher level cognitive function. Using event-related fMRI, subjects performed a simple sensory-motor activity allowing the measurement of the BOLD HRF in the precentral gyrus. There were no significant differences in the HRF when viewed as a function of age, hemisphere, or HIV serostatus. However, significant results were found after dividing the subjects by NIMH impairment classifications. There were 16 control subjects, 19 Normal/Asymptomatic Neuropsychological Impairment (ANI), and 11 Minor Neurocognitive Disorder (MNCD)/HIV-Associated Dementia (HAD) subjects. The HRF of MNCD/HAD subjects did not return to baseline after 16s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies.

Details

Language :
English
ISSN :
0165-0270
Volume :
163
Issue :
2
Database :
MEDLINE
Journal :
Journal of neuroscience methods
Publication Type :
Academic Journal
Accession number :
17540453
Full Text :
https://doi.org/10.1016/j.jneumeth.2007.03.004