Back to Search
Start Over
Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjects.
- Source :
-
Journal of neuroscience methods [J Neurosci Methods] 2007 Jul 30; Vol. 163 (2), pp. 208-12. Date of Electronic Publication: 2007 Mar 13. - Publication Year :
- 2007
-
Abstract
- Functional magnetic resonance imaging (fMRI) has revealed much about altered CNS function in HIV/AIDS. In this study, we compared the blood oxygen level dependent hemodynamic response function (BOLD HRF) signal in HIV/AIDS and control subjects as a necessary pre-condition for fMRI studies of higher level cognitive function. Using event-related fMRI, subjects performed a simple sensory-motor activity allowing the measurement of the BOLD HRF in the precentral gyrus. There were no significant differences in the HRF when viewed as a function of age, hemisphere, or HIV serostatus. However, significant results were found after dividing the subjects by NIMH impairment classifications. There were 16 control subjects, 19 Normal/Asymptomatic Neuropsychological Impairment (ANI), and 11 Minor Neurocognitive Disorder (MNCD)/HIV-Associated Dementia (HAD) subjects. The HRF of MNCD/HAD subjects did not return to baseline after 16s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies.
- Subjects :
- AIDS Dementia Complex diagnosis
AIDS Dementia Complex psychology
Adult
Aging
Brain virology
CD4 Lymphocyte Count
Cognition Disorders diagnosis
Cognition Disorders virology
Disability Evaluation
Female
HIV Seropositivity physiopathology
Humans
Male
Middle Aged
Neuropsychological Tests
Predictive Value of Tests
AIDS Dementia Complex physiopathology
Brain physiopathology
Cerebrovascular Circulation physiology
Cognition Disorders physiopathology
Magnetic Resonance Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 0165-0270
- Volume :
- 163
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neuroscience methods
- Publication Type :
- Academic Journal
- Accession number :
- 17540453
- Full Text :
- https://doi.org/10.1016/j.jneumeth.2007.03.004