[Hypercalcaemia and malignant lymphoma. One case report].

Authors :: Frein D
Lavigne C
Josselin N
Foussard C
Sivova N
Moles MP
Berrut G
Source :: La Revue de medecine interne [Rev Med Interne] 2007 Oct; Vol. 28 (10), pp. 714-5. Date of Electronic Publication: 2007 May 22.
Publication Year :: 2007
Abstract: Hypercalcaemia occurs in less than 15% of lymphomas but is associated with a poor prognosis. A patient known to have a testicular lymphoma was admitted because of asthenia and weight loss. Hypercalcemia and high serum level of calcitriol were found. A high-grade lymphoma attesting a Richter's syndrome was diagnosed. Palliative treatment consisting in corticosteroids and pamidronate was instituted. Hypercalcaemia in lymphoma has a poor prognosis and is often attributed to an acquired uncontrolled vitamin D 1-alpha-hydroxylase activity by the macrophages close to the lymphomatous cells. Influences of TNFalpha, interleukine 6 and PTHrp are also reported.