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Expression level of beta-catenin is associated with prognosis of esophageal carcinoma.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2007 May 14; Vol. 13 (18), pp. 2622-5. - Publication Year :
- 2007
-
Abstract
- Aim: To examine the association of beta-catenin with the clinicopathologic features and prognosis of esophageal squamous cell carcinoma (ESCC).<br />Methods: Beta-catenin mRNA expression level in 40 ESCC patients (28 males and 12 females, age range 38-82 years, median 60 years) was analyzed by real-time PCR. Beta-catenin mRNA expression levels in tumor cells were categorized as weaker (level 1) or equal to or stronger (level 2) than those in endothelial cells. We examined the correlation between the beta-catenin expression and the clinicopathological factors and prognosis of ESCC patients.<br />Results: Level 2 beta-catenin expression was found in 29 patients. ESCC with level 2 expression had a higher rate of lymphnode metastasis (0.0776 +/- 0.0369 vs 0.3413 +/- 0.1803, P < 0.001) and deeper tumor invasion (0.0751 +/- 0.0356 vs 0.3667 +/- 0.1928, P < 0.001), and a poorer survival rate (P = 0.0024) than ESCC with level 1 expression.<br />Conclusion: Beta-catenin expression in ESCC is of great importance.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor genetics
Carcinoma, Squamous Cell pathology
Esophageal Neoplasms pathology
Female
Humans
Male
Middle Aged
Prognosis
Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell mortality
Esophageal Neoplasms genetics
Esophageal Neoplasms mortality
beta Catenin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1007-9327
- Volume :
- 13
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 17552014
- Full Text :
- https://doi.org/10.3748/wjg.v13.i18.2622