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The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder.
- Source :
-
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2008 Jan 05; Vol. 147B (1), pp. 54-8. - Publication Year :
- 2008
-
Abstract
- Glycine transporter (GlyT)-1 plays a pivotal role in maintaining the glycine level at the glutamatergic synapse. Glycine is an allosteric agonist of N-methyl-D-aspartate (NMDA) receptors. Because activation of NMDA receptors is an essential step for induction of methamphetamine dependence and psychosis, differences in the functioning of GlyT-1 due to genetic variants of the GlyT-1 gene (GLYT1) may influence susceptibility. A case-control genetic association study of the GLYT1 gene examined 204 patients with methamphetamine-use disorder and 210 healthy controls. We examined three single nucleotide polymorphisms (SNPs), SNP1, IVS3 + 411C > T, rs2486001; SNP2, 1056G > A, rs2248829; and SNP3, IVS11 + 22G > A, rs2248632, of the GLYT1 gene and found that SNP1 showed a significant association in both genotype (P = 0.0086) and allele (P = 0.0019) with methamphetamine-use disorder. The T-G haplotype at SNP1 and SNP2 was a significant risk factor for the disorder (P = 0.000039, odds ratio: 2.04). The present findings indicate that genetic variation of the GLYT1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis.<br /> ((c) 2007 Wiley-Liss, Inc.)
- Subjects :
- Adult
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Amphetamine-Related Disorders genetics
Glycine Plasma Membrane Transport Proteins genetics
Methamphetamine toxicity
Polymorphism, Single Nucleotide
Psychoses, Substance-Induced genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1552-485X
- Volume :
- 147B
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 17582620
- Full Text :
- https://doi.org/10.1002/ajmg.b.30565