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Lymphoepithelioma-like carcinoma of the trachea.
- Source :
-
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia [Ann Thorac Cardiovasc Surg] 2007 Jun; Vol. 13 (3), pp. 191-4. - Publication Year :
- 2007
-
Abstract
- Lymphoepithelioma is a lymphocyte-rich, poorly differentiated and non-keratinizing squamous cell carcinoma of the nasopharynx. Tumors arising outside the nasopharynx are rare and are designated as lymphoepithelioma-like carcinomas (LELCs). This is the third reported case of LELC of the trachea. A 27-year-old woman was referred to our hospital on suspicion of bronchial asthma on August 2000. A polypoid tumor of the cervical trachea was recognized on neck X-ray, neck computed tomography (CT) scan, and fiberoptic bronchoscopy. The protruding tumor was resected endoscopically by an electrosurgical snare. Histological and immunohistochemical examinations demonstrated large irregular polygonal cells extending in an islet or trabecular pattern among lymphoid stroma. These polygonal cells showed non-keratinization, atypia and prominent nucleoli. In situ hybridization showed these cells were infected with the Epstein-Barr (EB) virus. The infiltrating lymphocytes consisted of both T-and B-lymphocytes with no atypia. Thus the tumor was diagnosed as LELC. Blood examination revealed a past EB viral infection. Sphenoid resection of the tracheal cartilaginous portion was performed for residual tumor. We gave 50 Gy postoperative radiation, and she has been disease free in the 6-year follow-up period.
- Subjects :
- Adult
Bronchoscopy
Carcinoma, Squamous Cell diagnosis
Carcinoma, Squamous Cell radiotherapy
Carcinoma, Squamous Cell surgery
Combined Modality Therapy
Epithelium pathology
Female
Humans
Mucous Membrane pathology
Radiotherapy Dosage
Tracheal Neoplasms diagnosis
Tracheal Neoplasms radiotherapy
Tracheal Neoplasms surgery
Carcinoma, Squamous Cell pathology
Tracheal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1341-1098
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
- Publication Type :
- Academic Journal
- Accession number :
- 17592428