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Lipoteichoic acid may affect the pathogenesis of PBC-like bile duct damage and might be involved in systemic multifocal epithelial inflammations in chronic colitis-harboring TCRalpha-/-xAIM-/- mice.
- Source :
-
Autoimmunity [Autoimmunity] 2007 Jul; Vol. 40 (5), pp. 372-9. - Publication Year :
- 2007
-
Abstract
- Background: Chronic colitis-harboring TCRalpha(- / - ) x AIM(- / - ) mice showed PBC-like bile duct damage in the liver. Bacterial infection is one of the candidates for the pathogenesis of PBC. We demonstrated that the bacterial cell wall component lipotheicoic acid (LTA) was detected at sites of inflammation around damaged bile ducts in PBC patients. The aim of this study was to investigate the pathophysiology of the liver and other organs in TCRalpha(- / - ) x AIM(- / - ) mice.<br />Methods: Thirteen female TCRalpha(- / - ) x AIM(- / - ) mice were sacrificed at 24 weeks of age. The liver, stomach, small intestine, colon, pancreas, kidney and spleen were studied for pathological examination. Using anti-LTA antibody as the primary antibody, an immunohistochemical study was carried out.<br />Results: In the liver, LTA was mainly detected in the portal area with inflammation, and some of the cytoplasm of hepatocytes. Inflammations were also observed in the stomach, intestine, pancreas and kidney. Throughout the gastrointestinal tract, from the stomach to the colon, LTA was detected in the epithelium at sites of inflammation. Furthermore, LTA was detected around both pancreatic ducts with inflammation and distal renal tubules with inflammation.<br />Conclusions: The development of inflammations in the liver as well as extensive organs, strongly suggests a close relationship between bile duct damage and systemic multifocal epithelial inflammations, perhaps involving bacterial LTA, in TCRalpha(- / - ) x AIM(- / - ) mice.
- Subjects :
- Animals
Bile Ducts, Intrahepatic cytology
Bile Ducts, Intrahepatic microbiology
Chronic Disease
Colitis microbiology
Colitis pathology
Epithelium immunology
Epithelium microbiology
Epithelium pathology
Female
Gram-Positive Bacteria metabolism
Gram-Positive Bacteria pathogenicity
Intestine, Small immunology
Intestine, Small microbiology
Intestine, Small pathology
Kidney immunology
Kidney microbiology
Kidney pathology
Liver immunology
Liver microbiology
Liver pathology
Liver Cirrhosis, Biliary microbiology
Liver Cirrhosis, Biliary pathology
Mice
Pancreas immunology
Pancreas microbiology
Pancreas pathology
Spleen immunology
Spleen microbiology
Spleen pathology
Bile Ducts, Intrahepatic immunology
Colitis immunology
Inflammation immunology
Lipopolysaccharides analysis
Liver Cirrhosis, Biliary immunology
Teichoic Acids analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0891-6934
- Volume :
- 40
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Autoimmunity
- Publication Type :
- Academic Journal
- Accession number :
- 17612899
- Full Text :
- https://doi.org/10.1080/08916930701402392