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Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia.
- Source :
-
Peptides [Peptides] 2007 Jul; Vol. 28 (7), pp. 1441-6. Date of Electronic Publication: 2007 Jun 14. - Publication Year :
- 2007
-
Abstract
- Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are involved in various biological functions including pain. High density of NOP receptor has been found in the ventrolateral periaqueductal gray (vlPAG), the main output pathway involved in descending pain-control system. The aim of our work was to evaluate the involvement of the N/OFQ/NOP system in the modulation of MOP analgesia in the rat vlPAG using UFP-101, a selective NOP antagonist. N/OFQ significantly blocked DAMGO (a selective MOP agonist) analgesia, while UFP-101 enhanced the effect of the opioid given at a subanalgesic dose. These results confirm our hypothesis of an antiopioid role for N/OFQ in the vlPAG.
- Subjects :
- Analgesics, Opioid administration & dosage
Animals
Enkephalin, Ala(2)-MePhe(4)-Gly(5)- administration & dosage
Male
Opioid Peptides administration & dosage
Opioid Peptides metabolism
Opioid Peptides pharmacology
Pain Measurement
Periaqueductal Gray metabolism
Rats
Rats, Sprague-Dawley
Receptors, Opioid metabolism
Nociceptin Receptor
Nociceptin
Analgesics, Opioid pharmacology
Enkephalin, Ala(2)-MePhe(4)-Gly(5)- pharmacology
Narcotic Antagonists
Opioid Peptides antagonists & inhibitors
Periaqueductal Gray drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0196-9781
- Volume :
- 28
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Peptides
- Publication Type :
- Academic Journal
- Accession number :
- 17628212
- Full Text :
- https://doi.org/10.1016/j.peptides.2007.05.013