Back to Search
Start Over
Aloe-emodin-induced apoptosis in human gastric carcinoma cells.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2007 Nov; Vol. 45 (11), pp. 2296-303. Date of Electronic Publication: 2007 Jun 12. - Publication Year :
- 2007
-
Abstract
- The purpose of this study was to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two distinct human gastric carcinoma cell lines, AGS and NCI-N87. We demonstrate that aloe-emodin induced cell death in a dose- and time-dependent manner. Noteworthy is that the AGS cells were generally more sensitive than the NCI-N87 cells. Aloe-emodin caused the release of apoptosis-inducing factor and cytochrome c from mitochondria, followed by the activation of caspase-3, leading to nuclear shrinkage and apoptosis. In addition, exposure to aloe-emodin suppressed the casein kinase II activity in a time-dependent manner and was accompanied by a reduced phosphorylation of Bid, a downstream substrate of casein kinase II and a pro-apoptotic molecule. These preclinical studies suggest that aloe-emodin represents a suitable and novel chemotherapeutic drug candidate for the treatment of human gastric carcinoma.
- Subjects :
- Apoptosis Inducing Factor
BH3 Interacting Domain Death Agonist Protein metabolism
Casein Kinase II metabolism
Cell Line, Tumor
Cytochromes c
Dose-Response Relationship, Drug
Humans
Phosphorylation
Time Factors
Anthraquinones pharmacology
Antineoplastic Agents, Phytogenic pharmacology
Apoptosis drug effects
Carcinoma drug therapy
Stomach Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0278-6915
- Volume :
- 45
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 17637488
- Full Text :
- https://doi.org/10.1016/j.fct.2007.06.005