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One-year follow-up of Coll2-1, Coll2-1NO2 and myeloperoxydase serum levels in osteoarthritis patients after hip or knee replacement.
- Source :
-
Annals of the rheumatic diseases [Ann Rheum Dis] 2008 Feb; Vol. 67 (2), pp. 168-74. Date of Electronic Publication: 2007 Jul 20. - Publication Year :
- 2008
-
Abstract
- Objectives: To determine Coll2-1, Coll2-1NO(2) and myeloperoxydase (MPO) levels in serum of patients with knee or hip osteoarthritis (OA) before the surgery, 3 months and 1 year after knee or hip replacement.<br />Methods: Coll2-1, Coll2-1NO(2) and MPO were measured in 103 patients with isolated symptomatic knee or hip OA candidates for joint replacement. Sera were taken the day before surgery, 3 months and 1 year after hip or knee replacement. Coll2-1 and Coll2-1NO(2) immunohistochemistry was performed on biopsies removed from cartilage lesions.<br />Results: Immunostainings revealed the extensive presence of Coll2-1 and Coll2-1NO(2) in the superficial layer of fibrillated cartilage and around some chondrocytes clusters. Three months after joint replacement, Coll2-1 and MPO serum levels were decreased and even reached the reference value for Coll2-1. By contrast, Coll2-1NO(2) levels remained elevated. At 1-year follow-up, Coll2-1 levels remained at the reference value, MPO levels were similar to those measured at 3 months, and Coll2-1NO(2) levels were unchanged and comparable to the pre-surgery values. However, in patients with pre-surgery values above the median (more than 0.42 nM), Coll2-1NO(2) levels significantly and progressively decreased post-operatively, but tended towards an increase in patients with pre-surgery Coll2-1NO(2) values below the median.<br />Conclusions: The normalisation of Coll2-1 levels 3 months after surgery indicates that Coll2-1 is a disease-specific marker that is sensitive to the structural changes occurring in a single joint. Furthermore, the immunohistochemical findings are consistent with the concept that the major source of serum Coll2-1 is the damaged articular cartilage. Finally, serum MPO levels decreased after joint replacement indicating that neutrophil activation occurs in OA joints, even in the late stage of the disease.
- Subjects :
- Aged
Aged, 80 and over
Arthroplasty, Replacement, Hip
Arthroplasty, Replacement, Knee
Biomarkers blood
Biomarkers metabolism
Cartilage, Articular chemistry
Collagen Type II blood
Female
Follow-Up Studies
Humans
Male
Middle Aged
Osteoarthritis, Hip surgery
Osteoarthritis, Knee surgery
Peptide Fragments blood
Reference Values
Collagen Type II metabolism
Osteoarthritis, Hip metabolism
Osteoarthritis, Knee metabolism
Peptide Fragments metabolism
Peroxidase blood
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2060
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annals of the rheumatic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 17644542
- Full Text :
- https://doi.org/10.1136/ard.2007.073452