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Xanthogranulomatous cholecystitis expressing high levels of DUPAN-II.
- Source :
-
Journal of gastroenterology [J Gastroenterol] 2007 Jul; Vol. 42 (7), pp. 593-6. Date of Electronic Publication: 2007 Jul 25. - Publication Year :
- 2007
-
Abstract
- We report a case of xanthogranulomatous cholecystitis (XGC) showing high levels of serum DUPAN-II in a 65-year-old woman. Preoperative radiologic examination showed no abnormal findings except in the gallbladder. Endoscopic ultrasonography was effective for differentiating chronic cholecystitis from gallbladder cancer before the operation. Cholecystectomy was performed by laparotomy, and the diagnosis of XGC was confirmed intraoperatively by examining a frozen section. Histologically, no cancer lesion was observed in the gallbladder, while immunochemical reactivity to DUPAN-II was demonstrated in the brush-border area of the epithelium and in histiocytes in the gallbladder. The half-life of serum DUPAN-II in our patient after cholecystectomy was approximately 1 month, and finally dropped to within the normal range after cholecystectomy.
- Subjects :
- Aged
Antigens, Neoplasm blood
Biomarkers, Tumor blood
Biomarkers, Tumor metabolism
Cholecystectomy
Cholecystitis diagnostic imaging
Endosonography
Epithelium metabolism
Female
Gallbladder pathology
Granuloma diagnostic imaging
Half-Life
Histiocytes metabolism
Humans
Laparotomy
Microvilli metabolism
Xanthomatosis diagnostic imaging
Antigens, Neoplasm metabolism
Cholecystitis physiopathology
Granuloma physiopathology
Xanthomatosis physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0944-1174
- Volume :
- 42
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 17653657
- Full Text :
- https://doi.org/10.1007/s00535-007-2063-7