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Depression following pegylated interferon-alpha: characteristics and vulnerability.
- Source :
-
Journal of psychosomatic research [J Psychosom Res] 2007 Aug; Vol. 63 (2), pp. 131-5. - Publication Year :
- 2007
-
Abstract
- Objective: Interferon-alpha2 (IFN-alpha) injections may be capable of triggering depression in some individuals. The first objective was to further characterize this depression and, secondly, to examine whether pre-treatment temperament was correlated with subsequent vulnerability to IFN-alpha.<br />Methods: Twenty-three initially euthymic adults undergoing year-long PEG-IFN-alpha treatment for hepatitis C were evaluated at baseline and then prospectively monitored using both the Structured Clinical Interview for DSM-IV (SCID) and self-report questionnaires.<br />Results: A major depressive episode developed within 3 months in 39%. Principal component analysis of the change in self-report scores after 1 month of treatment demonstrated three orthogonal factors: (i) a specific increase in depression as manifested in the Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS), (ii) an increase in hostility and anxiety, (iii) and a generalized combination of worse symptoms including somatic symptoms on the Symptom Check List (SCL-90). BDI at 1 month was predicted by baseline BDI (r=0.76, P=.004). Hostility at 1 month was predicted by low baseline agreeableness (r=0.75, P=.01). Controlling for baseline BDI scores, categorical major depression was predicted by combined high baseline neuroticism and low agreeableness (combined r=0.66, P=.03).<br />Conclusion: These initial results (i) support the depressogenic nature of IFN-alpha treatment in a subset of vulnerable individuals, (ii) indicate that some individuals are also independently vulnerable to worsened hostility, and (iii) suggest that it may be possible to clinically predict these vulnerabilities in initially euthymic subjects.
- Subjects :
- Adult
Antiviral Agents therapeutic use
Depressive Disorder, Major diagnosis
Diagnostic and Statistical Manual of Mental Disorders
Drug Hypersensitivity
Female
Hepatitis C drug therapy
Humans
Interferon-alpha therapeutic use
Male
Middle Aged
Surveys and Questionnaires
Antiviral Agents adverse effects
Depressive Disorder, Major chemically induced
Depressive Disorder, Major psychology
Interferon-alpha adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3999
- Volume :
- 63
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of psychosomatic research
- Publication Type :
- Academic Journal
- Accession number :
- 17662748
- Full Text :
- https://doi.org/10.1016/j.jpsychores.2007.05.013