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A metabolic sensor governing cell size in bacteria.
- Source :
-
Cell [Cell] 2007 Jul 27; Vol. 130 (2), pp. 335-47. - Publication Year :
- 2007
-
Abstract
- Nutrient availability is one of the strongest determinants of cell size. When grown in rich media, single-celled organisms such as yeast and bacteria can be up to twice the size of their slow-growing counterparts. The ability to modulate size in a nutrient-dependent manner requires cells to: (1) detect when they have reached the appropriate mass for a given growth rate and (2) transmit this information to the division apparatus. We report the identification of a metabolic sensor that couples nutritional availability to division in Bacillus subtilis. A key component of this sensor is an effector, UgtP, which localizes to the division site in a nutrient-dependent manner and inhibits assembly of the tubulin-like cell division protein FtsZ. This sensor serves to maintain a constant ratio of FtsZ rings to cell length regardless of growth rate and ensures that cells reach the appropriate mass and complete chromosome segregation prior to cytokinesis.
- Subjects :
- Bacillus subtilis growth & development
Bacterial Proteins metabolism
Bacterial Proteins ultrastructure
Chromosome Segregation genetics
Chromosomes, Bacterial metabolism
Cytoskeletal Proteins metabolism
Cytoskeletal Proteins ultrastructure
DNA Replication
Food
Models, Biological
Mutation genetics
Phenotype
Protein Transport
Uridine Diphosphate Glucose biosynthesis
Bacillus subtilis cytology
Bacillus subtilis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0092-8674
- Volume :
- 130
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 17662947
- Full Text :
- https://doi.org/10.1016/j.cell.2007.05.043