Back to Search
Start Over
Accumulation of risk factors enhances the prothrombotic state in atrial fibrillation.
- Source :
-
International journal of cardiology [Int J Cardiol] 2008 Jun 06; Vol. 126 (3), pp. 316-21. Date of Electronic Publication: 2007 Aug 08. - Publication Year :
- 2008
-
Abstract
- Background: The present study was conducted to investigate the relation between the accumulation of the risk factors of thromboembolism and the levels of hemostatic markers in patients with nonvalvular atrial fibrillation (NVAF).<br />Methods: Five hundred ninety-one NVAF patients and 129 control subjects were categorized into low, moderate or high risk of thromboembolism, according to CHADS(2) index. One point each was given to patients with advanced age (> or =75 years), hypertension, congestive heart failure, and diabetes mellitus, and 2 points, to those with prior ischemic stroke or transient ischemic attack. Patients with CHADS(2) score of 0, 1 or 2, and > or =3 were classified as low, moderate and high risk, respectively. Levels of hemostatic markers (platelet factor 4, beta-thromboglobulin, prothrombin fragment F1+2 and D-dimer) were determined.<br />Results: Of 591 patients with NVAF, 302 were treated with warfarin (mean international normalized ratio 1.88). D-dimer levels increased as the risk level increased irrespective of warfarin use. Particularly, NVAF patients without receiving warfarin (n=289) had significantly higher D-dimer levels than control patients (e.g., for high risk patients, 175+/-144 vs 75+/-87 ng/ml, p<0.001), while NVAF patients receiving warfarin had intermediate levels (136+/-156 ng/ml). F1+2 levels increased as the risk level increased, and were significantly suppressed by warfarin. Levels of markers of platelet activation (platelet factor 4 and beta-thromboglobulin) were increased in NVAF patients but not affected by the risk level.<br />Conclusion: Coagulation and fibrinolytic activity is increased along with the accumulation of the risk factors of thromboembolism in NVAF patients.
- Subjects :
- Age Distribution
Aged
Atrial Fibrillation diagnosis
Case-Control Studies
Comorbidity
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Platelet Factor 4 analysis
Probability
Prothrombin analysis
Reference Values
Risk Assessment
Severity of Illness Index
Sex Distribution
Stroke etiology
Survival Analysis
Thromboembolism diagnosis
Warfarin therapeutic use
beta-Thromboglobulin analysis
Anticoagulants therapeutic use
Atrial Fibrillation epidemiology
Fibrin Fibrinogen Degradation Products analysis
Stroke prevention & control
Thromboembolism drug therapy
Thromboembolism epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 126
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 17689760
- Full Text :
- https://doi.org/10.1016/j.ijcard.2007.06.020