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Effect of carbon dioxide pneumoperitoneum on liver function following laparoscopic cholecystectomy.
- Source :
-
Journal of laparoendoscopic & advanced surgical techniques. Part A [J Laparoendosc Adv Surg Tech A] 2007 Aug; Vol. 17 (4), pp. 419-24. - Publication Year :
- 2007
-
Abstract
- Background: It has been noted that following a laparoscopic cholecystectomy (LC), liver function parameters were disturbed. The causes of this disturbance are still controversial.<br />Patients and Methods: The serum levels of eight parameters of liver function were measured both before and 24 hours after surgery in 142 consecutive patients who underwent LC, 23 patients who underwent open cholecystectomy (OC), and in 25 patients who underwent a conventional hernial repair. The same anesthetic protocol was applied to all patients in the various groups and in the case of LC; the intra-abdominal pressure was maintained at 12 mmHg of CO2.<br />Results: Twenty-four (24) hours after surgery, there was a statistically significant change of all the eight parameters studied, except alkaline phosphatase in patients who underwent LC, whereas there were only 3 patients from the OC group who had changes of alanine aminotransferase and aspartite aminotransferase and 2 patients who had raised levels of direct bilirubin, and no changes were observed among those who had conventional hernial repair. We found that 83% of the patients showed more than a 100% increase in at least one parameter, 43% showed an increase in two or more parameters, and 23% showed an increase in three or more parameters. We also observed a significant drop of total proteins and albumin levels in all patients who had LC.<br />Conclusions: It appears that the pneumoperitoneum plays a major role in these changes. Although these changes of liver function were of no clinical relevance in healthy patients, the safety of the procedure must nonetheless be assessed in those with underlying liver diseases.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Carbon Dioxide
Cholelithiasis physiopathology
Cholelithiasis surgery
Female
Humans
Liver Diseases diagnosis
Male
Middle Aged
Postoperative Period
Prospective Studies
Cholecystectomy, Laparoscopic
Liver physiopathology
Liver Diseases etiology
Liver Function Tests
Pneumoperitoneum, Artificial adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1092-6429
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of laparoendoscopic & advanced surgical techniques. Part A
- Publication Type :
- Academic Journal
- Accession number :
- 17705719
- Full Text :
- https://doi.org/10.1089/lap.2006.0160