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The long and short of fatty acid synthesis.

Authors :
Riezman H
Source :
Cell [Cell] 2007 Aug 24; Vol. 130 (4), pp. 587-8.
Publication Year :
2007

Abstract

The multienzyme complex that synthesizes very long chain fatty acids is embedded in the membrane of the endoplasmic reticulum. In this issue, Denic and Weissman (2007) describe the reconstitution of this complex in liposomes and reveal how elongase proteins (Elops) determine the final length of the fatty acyl CoA chain.

Subjects

Subjects :
3-Oxoacyl-(Acyl-Carrier-Protein) Reductase
Acetyltransferases metabolism
Alcohol Oxidoreductases metabolism
Animals
Coenzyme A Ligases metabolism
Cytoplasm metabolism
Endoplasmic Reticulum enzymology
Escherichia coli Proteins isolation & purification
Escherichia coli Proteins metabolism
Fatty Acid Elongases
Humans
Hydro-Lyases metabolism
Liposomes chemistry
Models, Biological
Oxidoreductases metabolism
Fatty Acids, Nonesterified biosynthesis

Details

Language :
English
ISSN :
0092-8674
Volume :
130
Issue :
4
Database :
MEDLINE
Journal :
Cell
Publication Type :
Academic Journal
Accession number :
17719534
Full Text :
https://doi.org/10.1016/j.cell.2007.08.008
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