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Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Oct 01; Vol. 17 (19), pp. 5316-20. Date of Electronic Publication: 2007 Aug 16. - Publication Year :
- 2007
-
Abstract
- Two new alkaloids, hypserpanines A and B (1, 11), together with eleven known compounds, phenolbetain (2), acutumine (3), acutumidine (4), dechloroacutumine (5), dauricumine (6), dauricumidine (7), pronuciferine (8), glaziovine (9), S-reticuline (10), magnoflorine (12) and laurifoline(13), were isolated from Hypserpa nitida Miers. (Menispermaceae) and chemically elucidated through spectral analyses. All the isolated alkaloids were evaluated for their anti-HBV activities in vitro using the HBV transfected Hep G2.2.15 cell line. The most active compound, dauricumidine (7), exhibited an IC(50) value of 0.450 mM (SI=4.13) on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line.
- Subjects :
- Alkaloids chemistry
Antiviral Agents chemistry
Cell Line
Chromatography, Ion Exchange
Diethylamines chemistry
Hepatitis B Surface Antigens metabolism
Hepatitis B e Antigens metabolism
Heterocyclic Compounds, 3-Ring chemistry
Humans
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Spectrometry, Mass, Electrospray Ionization
Spiro Compounds chemistry
Alkaloids pharmacology
Antiviral Agents pharmacology
Diethylamines pharmacology
Hepatitis B virus drug effects
Heterocyclic Compounds, 3-Ring pharmacology
Menispermaceae chemistry
Spiro Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 17
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 17723297
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.08.027