Long lasting BCG protection against leprosy.

Authors :: Rodrigues LC
Kerr-Pontes LR
Frietas MV
Barreto ML
Source :: Vaccine [Vaccine] 2007 Sep 28; Vol. 25 (39-40), pp. 6842-4. Date of Electronic Publication: 2007 Aug 06.
Publication Year :: 2007
Abstract: Background: BCG vaccine protects against leprosy.<br />Objectives: Estimate BCG protection against leprosy by age by age.<br />Methods: A case control study with 226 cases of leprosy and 857 controls. BCG vaccination was ascertained via examination of BCG scars. Protection is presented for three age groups.<br />Results: BCG protection against leprosy was 86% (95% CI: 77-92%) in the age group 18-29; 54% (95% CI: -37% to 85%) in the age group 30-39 and 32% (95% CI: -3% to 56%) in those aged 40 or more.<br />Conclusions: BCG efficacy against leprosy may well last for three decades and possibly even longer. BCG vaccination must have contributed to worldwide reduction in leprosy incidence.