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Lack of correlation between embB mutation and ethambutol MIC in Mycobacterium tuberculosis clinical isolates from China.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2007 Dec; Vol. 51 (12), pp. 4515-7. Date of Electronic Publication: 2007 Sep 10. - Publication Year :
- 2007
-
Abstract
- Seventy-four Mycobacterium tuberculosis clinical isolates from China were subjected to drug susceptibility testing using ethambutol, isoniazid, rifampin, and ofloxacin. The results revealed that the presence of embB mutations did not correlate with ethambutol resistance but was associated with multiple-drug resistance, especially resistance to both ethambutol and rifampin.
- Subjects :
- Antitubercular Agents pharmacology
Bacterial Proteins genetics
China
Drug Resistance, Bacterial genetics
Humans
Isoniazid pharmacology
Microbial Sensitivity Tests
Mycobacterium tuberculosis isolation & purification
Ofloxacin pharmacology
Pentosyltransferases genetics
Rifampin pharmacology
Tuberculosis microbiology
Ethambutol pharmacology
Mutation
Mycobacterium tuberculosis drug effects
Mycobacterium tuberculosis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 51
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 17846128
- Full Text :
- https://doi.org/10.1128/AAC.00416-07