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[On the role of brain serotonin system in the pathway from gene to behaviour].

Authors :
Popova NK
Source :
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2007 Jun; Vol. 93 (6), pp. 569-75.
Publication Year :
2007

Abstract

This paper concentrates on involvement of protein elements in the brain neurotransmitter serotonin system (key enzymes in serotonin metabolism and 5-HT(1A) receptors) in the genetic control of behaviour. The data were obtained using Norway rats selected for more that 50 generations for lack of aggressive response and for aggressive behaviour towards humans (fear-induced aggression), inbred mouse strains, and MAO A knockout mice. The review provides converging line of evidence that: 1) brain serotonin contributes to critical mechanism underlying genetically defined individual differences in aggressiveness, and 2) genes encoding pivotal enzymes in serotonin metabolism (tryptophan hydroxylase, MAO A) and 5-HT(1A) receptors belong to a group of genes that modulate aggressive behaviour.

Details

Language :
Russian
ISSN :
0869-8139
Volume :
93
Issue :
6
Database :
MEDLINE
Journal :
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
Publication Type :
Academic Journal
Accession number :
17850016