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[Effects of Astragalus on expression of renal angiopoietin receptor Tie-2 in diabetic rats].
- Source :
-
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine [Zhong Xi Yi Jie He Xue Bao] 2007 Sep; Vol. 5 (5), pp. 536-40. - Publication Year :
- 2007
-
Abstract
- Objective: To study the expression of angiopoietin receptor Tie-2 in the renal tissue of diabetic rats and the effects of Astragalus.<br />Methods: SD rats were randomly divided into normal control group, diabetes group and Astragalus-treated group. The expression of receptor Tie-2 in the renal tissue was assessed by using real-time quantitative polymerase chain reaction and immunohistochemical method.<br />Results: Glomerule Tie-2 protein expression was significantly elevated in the diabetes group as compared with the normal control group (P<0.01). Glomerule Tie-2 protein expression in the Astragalus-treated group was decreased as compared with the diabetes group (P<0.01).<br />Conclusion: Tie-2 may play an important role in the pathogenesis of the early stage diabetic renal injury. The reno-protection effect of Astragalus may be mediated by down-regulating the expression of Tie-2 in the kidney tissue of diabetic rats.
- Subjects :
- Animals
Diabetes Mellitus, Experimental pathology
Diabetic Nephropathies metabolism
Down-Regulation
Kidney pathology
Male
Random Allocation
Rats
Rats, Sprague-Dawley
Astragalus propinquus chemistry
Diabetes Mellitus, Experimental metabolism
Kidney metabolism
Plant Extracts pharmacology
Receptor, TIE-2 metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1672-1977
- Volume :
- 5
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
- Publication Type :
- Academic Journal
- Accession number :
- 17854555
- Full Text :
- https://doi.org/10.3736/jcim20070512