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Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.
- Source :
-
Steroids [Steroids] 2007 Dec; Vol. 72 (14), pp. 939-48. Date of Electronic Publication: 2007 Aug 15. - Publication Year :
- 2007
-
Abstract
- A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17alpha-hydroxylase-C(17,20)-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.
- Subjects :
- Binding, Competitive drug effects
Cell Line, Tumor
Cell Proliferation drug effects
Dehydroepiandrosterone chemistry
Dehydroepiandrosterone toxicity
Humans
Male
Prostatic Neoplasms enzymology
Prostatic Neoplasms pathology
Receptors, Androgen metabolism
Steroid 17-alpha-Hydroxylase metabolism
Dehydroepiandrosterone analogs & derivatives
Dehydroepiandrosterone chemical synthesis
Dehydroepiandrosterone pharmacology
Steroid 17-alpha-Hydroxylase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0039-128X
- Volume :
- 72
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Steroids
- Publication Type :
- Academic Journal
- Accession number :
- 17884122
- Full Text :
- https://doi.org/10.1016/j.steroids.2007.08.004