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Nuclear medicine procedures in the diagnosis and therapy of medullary thyroid carcinoma.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2008 Mar; Vol. 62 (3), pp. 139-46. Date of Electronic Publication: 2007 Aug 20. - Publication Year :
- 2008
-
Abstract
- Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating in the parafollicular cells (C cells) of the thyroid and secretes both calcitonin and carcino-embryonic antigen (CEA). Genetic and biochemical testing allow early pre-clinical identification of familial forms. Sporadic MTC usually presents as a solitary thyroid nodule; the diagnosis can be made preoperatively by fine-needle aspiration or by calcitonin assay, though it is usually established at the time of surgery. In the diagnostic assessment of MTC, nuclear medicine imaging provides its contribution mainly in the post-operative work-up to detect residual/recurrent tumor. For such purpose a number of radiopharmaceuticals, which take advantage of the specific expression of receptors (the somatostatin analogue (111)In-octreotide), hormone transporters (radiolabelled MIBG) or molecular targets (radiolabelled anti-CEA monoclonal antibodies) by MTC lesions are available; these tracers may be used also for the palliative treatment of advanced MTC. Interesting perspectives for MTC imaging are offered by PET radiopharmaceuticals.
- Subjects :
- 3-Iodobenzylguanidine
Animals
Carcinoembryonic Antigen immunology
Humans
Iodine Radioisotopes
Positron-Emission Tomography
Somatostatin analogs & derivatives
Somatostatin pharmacology
Tomography, Emission-Computed, Single-Photon
Carcinoma, Medullary diagnostic imaging
Carcinoma, Medullary radiotherapy
Nuclear Medicine
Radiopharmaceuticals therapeutic use
Thyroid Neoplasms diagnostic imaging
Thyroid Neoplasms radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 0753-3322
- Volume :
- 62
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 17892924
- Full Text :
- https://doi.org/10.1016/j.biopha.2007.07.011