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Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Nov 15; Vol. 17 (22), pp. 6151-4. Date of Electronic Publication: 2007 Sep 14. - Publication Year :
- 2007
-
Abstract
- Vitronectin receptor (alpha(V)beta(3)) antagonists have been implicated as a possible new treatment of restenosis following balloon angioplasty. In this work we investigate a series of novel arginine mimetic scaffolds leading to new insight of the alpha(V)beta(3)/ligand interaction. Squaric acid amide 10 is a subnanomolar alpha(V)beta(3) antagonist with improved potency on human smooth muscle cell migration.
- Subjects :
- Binding Sites drug effects
Biphenyl Compounds chemistry
Cyclobutanes chemistry
Humans
Ligands
Models, Molecular
Molecular Structure
Protein Structure, Tertiary
Receptors, Vitronectin chemistry
Structure-Activity Relationship
Sulfonamides chemistry
Biphenyl Compounds pharmacology
Cyclobutanes pharmacology
Receptors, Vitronectin antagonists & inhibitors
Sulfonamides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 17
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 17910915
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.09.039