Back to Search Start Over

Anti-Ro52 antibodies, antisynthetase antibodies, and antisynthetase syndrome.

Anti-Ro52 antibodies, antisynthetase antibodies, and antisynthetase syndrome.

Authors :
Limaye VS
Cassidy J
Scott G
Roberts-Thomson PJ
Gillis D
Source :
Clinical rheumatology [Clin Rheumatol] 2008 Apr; Vol. 27 (4), pp. 521-3. Date of Electronic Publication: 2007 Oct 11.
Publication Year :
2008

Abstract

We present a case of antisynthetase syndrome manifesting with interstitial lung disease, mechanic's hands, nailfold abnormalities, and subclinical myositis, in the presence of antibodies to the aminoacyl tRNA synthetase PL-12 and also to Ro52. Antibodies to Ro52 have been recently associated with idiopathic inflammatory myositis, but there have only been occasional reports of this antibody occurring in association with aminoacyl tRNA synthetases, including PL-12. Our case adds to the descriptions of the concurrence of antibodies to PL-12 and Ro52. The mechanism for the coupling of antibody response remains elusive but is likely to play a fundamental role in disease pathogenesis.

Details

Language :
English
ISSN :
0770-3198
Volume :
27
Issue :
4
Database :
MEDLINE
Journal :
Clinical rheumatology
Publication Type :
Academic Journal
Accession number :
17929074
Full Text :
https://doi.org/10.1007/s10067-007-0762-3