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[The preliminary application of autologous platelet-rich gel used to treat refractory diabetic dermal ulcer].
- Source :
-
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2007 Sep; Vol. 38 (5), pp. 900-3. - Publication Year :
- 2007
-
Abstract
- Objective: To assess the effectiveness and security of autologous platelet-rich gel (APG) in the treatment of refractory diabetic dermal ulcers.<br />Methods: Thirteen diabetic patients with refractory skin lesions were enrolled for this study, and APG was produced by platelet (PLT)-rich plasma (PRP) with thrombin and calcium gluconate. APG treatment consisted of wound dressed with APG, followed by topical washing and cleaning. The APG was then covered with Vaseline gauze and left for 48 to 72 hours, after which the wounds were treated conventionally until the next PLT-gel treatment. The clinical endpoints of the study were the healing rate.<br />Results: A total of 13 patients entered the pilot study. There were no drop-outs in the study. 69.2% ulcers were cured, and especially the ulcer areas were reduced significantly in the first 3 weeks; no adverse reactions were observed.<br />Conclusion: Topical therapy with APG may be considered as an effective adjuvant method to treating refractory diabetic dermal ulcer.
- Subjects :
- Adolescent
Adult
Aged
Calcium Gluconate administration & dosage
Calcium Gluconate therapeutic use
Female
Humans
Middle Aged
Pilot Projects
Platelet-Rich Plasma
Thrombin administration & dosage
Thrombin therapeutic use
Treatment Outcome
Wound Healing
Young Adult
Blood Platelets
Diabetes Complications
Gels administration & dosage
Skin Ulcer therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1672-173X
- Volume :
- 38
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
- Publication Type :
- Academic Journal
- Accession number :
- 17953386