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Effect of antiglaucoma agents on postoperative intraocular pressure after cataract surgery with Viscoat.
- Source :
-
Journal of cataract and refractive surgery [J Cataract Refract Surg] 2007 Nov; Vol. 33 (11), pp. 1941-5. - Publication Year :
- 2007
-
Abstract
- Purpose: To compare the effectiveness of brinzolamide 1%, brimonidine 0.2%, acetazolamide 250 mg, intracameral acetylcholine, and timolol 0.5% in preventing intraocular pressure (IOP) peaks during the early period after phacoemulsification in which sodium chondroitin sulfate 4%-sodium hyaluronate 3% (Viscoat) was used as the ophthalmic viscosurgical device (OVD).<br />Setting: Department of Ophthalmology, Baskent University Medical Faculty, Ankara, Turkey.<br />Methods: This prospective randomized study comprised 185 eyes of 185 patients with uncomplicated cataract scheduled for phacoemulsification using Viscoat as the OVD. Patients were randomly assigned to 1 of 6 groups: postoperative application of topical brinzolamide 1%, brimonidine 0.2%, oral acetazolamide 250 mg, intracameral acetylcholine, timolol 0.5%, or no ocular hypotensive agent (control group). The IOP was measured at baseline (preoperatively) as well as 6 hours, 20 to 24 hours, and 1 week after surgery.<br />Results: The mean preoperative IOP values were not significantly different between the groups. Six hours and 20 to 24 hours postoperatively, the mean IOP was significantly lower in all groups receiving an ocular hypotensive agent than in the control group (P<.01). Six hours after surgery, the mean IOP significantly increased in all groups but was higher in the control group. At 20 to 24 hours, the mean IOP decreased significantly in all ocular hypotensive agent groups but remained significantly high in the control group. One week after surgery, there were no significant differences between the groups.<br />Conclusion: Brinzolamide, brimonidine, acetazolamide, intracameral acetylcholine, and timolol had similar effects in reducing IOP increases after phacoemulsification performed using Viscoat.
- Subjects :
- Acetazolamide administration & dosage
Acetylcholine administration & dosage
Administration, Topical
Aged
Aged, 80 and over
Brimonidine Tartrate
Chondroitin Sulfates
Double-Blind Method
Drug Combinations
Female
Humans
Lens Implantation, Intraocular
Male
Middle Aged
Prospective Studies
Quinoxalines administration & dosage
Sulfonamides administration & dosage
Thiazines administration & dosage
Timolol administration & dosage
Tonometry, Ocular
Antihypertensive Agents administration & dosage
Chondroitin therapeutic use
Hyaluronic Acid therapeutic use
Intraocular Pressure drug effects
Ocular Hypertension prevention & control
Phacoemulsification
Postoperative Complications prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0886-3350
- Volume :
- 33
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of cataract and refractive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 17964402
- Full Text :
- https://doi.org/10.1016/j.jcrs.2007.06.046