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A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2007 Oct; Vol. 60 (10), pp. 645-8. - Publication Year :
- 2007
-
Abstract
- A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.
- Subjects :
- Anti-Bacterial Agents isolation & purification
Antifungal Agents isolation & purification
Antifungal Agents pharmacology
Bacteria drug effects
Chemical Phenomena
Chemistry, Physical
Diterpenes isolation & purification
Fungi drug effects
Indoles isolation & purification
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Conformation
Mycelium chemistry
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Anti-Bacterial Agents pharmacology
Ascomycota chemistry
Diterpenes pharmacology
Indoles pharmacology
Methicillin Resistance
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 60
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 17965481
- Full Text :
- https://doi.org/10.1038/ja.2007.83