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Evaluation of two different potency tests for leptospirosis vaccine vax-SPIRAL.

Authors :
Núñez JF
Fajardo EM
Pérez E
Ontivero I
Silva D
Muñoz P
Source :
Revista cubana de medicina tropical [Rev Cubana Med Trop] 2005 Jan-Apr; Vol. 57 (1), pp. 67-8.
Publication Year :
2005

Abstract

Two different potency tests were evaluated, consisting in one-dilution used to determine 50% lethal dose (LD50) and four--dilution used to calculate 50% effective dose (ED50), respectively. Our experience has led to propose the four-dilution test for routine lot releasing.

Subjects

Subjects :
Animals
Bacterial Vaccines toxicity
Cricetinae
Cuba
Follow-Up Studies
Leptospira pathogenicity
Lethal Dose 50
Time Factors
Toxicity Tests
Bacterial Vaccines standards
Leptospira immunology
Leptospirosis prevention & control

Details

Language :
English
ISSN :
0375-0760
Volume :
57
Issue :
1
Database :
MEDLINE
Journal :
Revista cubana de medicina tropical
Publication Type :
Academic Journal
Accession number :
17966487

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Authors Abstract Subjects Details