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Development and regeneration of hair cells share common functional features.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2007 Nov 27; Vol. 104 (48), pp. 19108-13. Date of Electronic Publication: 2007 Nov 19. - Publication Year :
- 2007
-
Abstract
- The structural phenotype of neural connections in the auditory brainstem is sculpted by spontaneous and stimulus-induced neural activities during development. However, functional and molecular mechanisms of spontaneous action potentials (SAPs) in the developing cochlea are unknown. Additionally, it is unclear how regenerating hair cells establish their neural ranking in the constellation of neurons in the brainstem. We have demonstrated that a transient Ca(2+) current produced by the Ca(v)3.1 channel is expressed early in development to initiate spontaneous Ca(2+) spikes. Ca(v)1.3 currents, typical of mature hair cells, appeared later in development. Moreover, there is a surprising disappearance of the Ca(v)3.1 current that coincides with the attenuation of the transient Ca(2+) current as the electrical properties of hair cells transition to the mature phenotype. Remarkably, this process is recapitulated during hair-cell regeneration, suggesting that the transient expression of Ca(v)3.1 and the ensuing SAPs are signatures of hair cell development and regeneration.
- Subjects :
- Action Potentials drug effects
Animals
Calcium Channel Blockers pharmacology
Calcium Signaling
Chick Embryo
Chickens
Cochlea drug effects
Cochlea embryology
Cochlea growth & development
Gentamicins toxicity
Hair Cells, Auditory drug effects
Mibefradil pharmacology
Nickel pharmacology
Patch-Clamp Techniques
Scorpion Venoms pharmacology
Calcium Channels, L-Type physiology
Calcium Channels, T-Type physiology
Cochlea physiology
Hair Cells, Auditory cytology
Regeneration
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 104
- Issue :
- 48
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 18025474
- Full Text :
- https://doi.org/10.1073/pnas.0705927104