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The biological role of dectin-1 in immune response.
- Source :
-
International reviews of immunology [Int Rev Immunol] 2007 Sep-Dec; Vol. 26 (5-6), pp. 349-64. - Publication Year :
- 2007
-
Abstract
- The identification of antigen-recognizing receptors in the innate immune system significantly helped us to understand the initiation and regulation of the innate immune response. Dectin-1 was recently identified as the most important receptor for beta-glucan. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. In this paper, we will mainly focus on the characteristics of dectin-1 and its biological role in immune response.
- Subjects :
- Animals
Antigen-Presenting Cells metabolism
Cytokines immunology
Humans
Immunity, Innate
Lectins, C-Type
Membrane Proteins chemistry
Membrane Proteins genetics
Membrane Proteins immunology
Nerve Tissue Proteins chemistry
Nerve Tissue Proteins genetics
Nerve Tissue Proteins immunology
Phagocytosis
Protein Isoforms
Signal Transduction
T-Lymphocyte Subsets metabolism
beta-Glucans immunology
Antigen-Presenting Cells immunology
Cytokines metabolism
Membrane Proteins physiology
Mycoses immunology
Nerve Tissue Proteins physiology
T-Lymphocyte Subsets immunology
beta-Glucans metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0883-0185
- Volume :
- 26
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- International reviews of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 18027205
- Full Text :
- https://doi.org/10.1080/08830180701690793