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Inflammatory response in on- versus off-pump myocardial revascularization: is ECC really the culprit?
- Source :
-
The Thoracic and cardiovascular surgeon [Thorac Cardiovasc Surg] 2007 Dec; Vol. 55 (8), pp. 473-80. - Publication Year :
- 2007
-
Abstract
- A review of inflammatory mediators in on- versus off-pump surgery reveals that parameters of systemic inflammation differ quantitatively, not qualitatively between these approaches. Mediator system and cellular activation is observed after surgical trauma and following ischemia/reperfusion. Such activation is also modulated by genetic factors. The available literature does not permit definitive conclusions to be made on the advantages of off-pump surgery with respect to the systemic inflammatory response. The relationship between mediator systems and clinical course needs to be assessed in large patient populations to demonstrate to what extent off-pump surgery is more than just theoretically superior to on-pump surgery.
- Subjects :
- Complement Activation
Coronary Artery Bypass, Off-Pump adverse effects
Extracorporeal Circulation adverse effects
Humans
Inflammation
Myocardial Revascularization
Risk Factors
Coronary Artery Bypass, Off-Pump methods
Cytokines metabolism
Extracorporeal Circulation methods
Immunity, Cellular physiology
Myocardial Ischemia surgery
Oxidative Stress physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0171-6425
- Volume :
- 55
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Thoracic and cardiovascular surgeon
- Publication Type :
- Academic Journal
- Accession number :
- 18027331
- Full Text :
- https://doi.org/10.1055/s-2007-965631